Pain, Oh Yes. I had pain so bad in all my joints that I cried all day some times. But when I went to the arthritis doctor, the pain was not in my joints. It was in the area around my joints. I began taking Cymbalta for my depressions before they knew it was good for fibromyalgia. It worked. Because it worked, the doctor diagnosed me with fibro and sarcoidosis. Either way, it worked. If I forget to take it, I get the pain back within a few hours.